ISOKEM™

Advancing Precision Measurement of Biological Activity

Harnessing molecular metabolism through atomic-tagging technologies to enable precision measurement of biological flux activity across clinical diagnostics, translational research, and biotechnology as a new class of measurement.

DEVELOPMENT STATUS

IP established, July 2025.

International PCT, filed July 2026.

NIH SBIR Phase I (R43) Application Submitted

ISOKEM-X: Metabolism Based Detection of Viable Bacterial Infection

A coordinated, multi-site laboratory research program for feasibility and development of ISOKEM-X.

NIH Application ID:
11637957
Principal Investigator:
Peter Gaied, D.O.
Proposed project period:
April 12–October 15, 2027
NIH Research Alignment:
NIAID/DMID High-Priority Area

“Development of rapid, highly sensitive and specific clinical diagnostics that are easy to use, cost-effective, and can diagnose individuals infected with pathogens”

NIAID/DMID · Small Business High-Priority Areas of Interest (excerpt)

Applications

ITRACE

U.S. Patent Pending No. 19/270,779

International (PCT) No. PCT/US26/36378

Rapid, breath-based, point-of-care assessment of viable bacterial infection in vivo, designed to enable earlier diagnostic readout and support biologically aligned clinical decision-making.

ISOKEM-X

U.S. Patent Pending No. 19/755,655

Rapid, point-of-care assessment of infected biologic samples across blood, urine, cerebrospinal fluid, bronchoalveolar lavage, peritoneal fluid, tissue suspensions, and other ex vivo biologic samples, designed to move infectious disease diagnostics beyond delayed culture, indirect biomarkers, and cohort-derived statistical inference.

KEMFlux

U.S. Patent Pending No. 19/688,479

Continuous, real-time monitoring of pathway kinetics through direct measurement of enzymatic flux, designed to replace labor-intensive and destructive reconstruction workflows across laboratory research and industrial biotechnology.